TMB-8 prevents the hydroosmotic response to ADH in rabbit cortical collecting tubules
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چکیده
منابع مشابه
Bicarbonate secretion by rabbit cortical collecting tubules in vitro.
We previously reported that rabbit renal cortical collecting tubules can secrete bicarbonate in vitro (i.e., there can be net transport from bath to lumen, causing the concentration in the lumen to increase). Net bicarbonate secretion was observed most often when rabbits had been pretreated with NaHCO(3) and were excreting alkaline urine before being killed for experiments. The purpose of the p...
متن کاملOsmosis in Cortical Collecting Tubules
This paper reports a theoretical analysis of osmotic transients and an experimental evaluation both of rapid time resolution of lumen to bath osmosis and of bidirectional steady-state osmosis in isolated rabbit cortical collecting tubules exposed to antidiuretic hormone (ADH). For the case of a membrane in series with unstirred layers, there may be considerable differences between initial and s...
متن کاملThe single nephron preparation--cortical collecting tubules.
As Dr. Burg has pointed out, the rabbit has practically the only kidney fromi which nephrons can be dissected conveniently. We have dissected collecting tubules from human kidneys recently, but dissection of the rabbit kidney is far easier and the supply of kidneys certainly more dependable. Two points about the renal anatomy in the rabbit need to be emphasized. First of all, the cortical colle...
متن کاملInhibition by lithium of the hydroosmotic action of vasopressin in the isolated perfused cortical collecting tubule of the rabbit.
Because treatment with lithium salts may impair renal concentrating ability, we investigated the possibility of a direct effect of lithium ions on the permeability to water of the collecting duct epithelium. The coefficient of hydraulic conductivity (Lp) of isolated perfused rabbit cortical collecting tubules (CCT) was measured in the presence and absence of arginine-8-vasopressin (AVP), or 8-b...
متن کاملEpidermal growth factor inhibits the hydroosmotic effect of vasopressin in the isolated perfused rabbit cortical collecting tubule.
Epidermal growth factor (EGF) is a 53-amino acid polypeptide which is a potent mitogen for cultured cells. The kidney has recently been shown to be a major site of synthesis for the EGF precursor. EGF infusions in sheep result in a diuresis and natriuresis despite a fall in GFR, suggesting a direct tubular effect. Using in vitro microperfusion of rabbit cortical collecting tubules (CCTs) at 37 ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1991
ISSN: 0085-2538
DOI: 10.1038/ki.1991.230